Detalles de la búsqueda
1.
Class A capsid assembly modulator apoptotic elimination of hepatocytes with high HBV core antigen level in vivo is dependent on de novo core protein translation.
J Virol
; 98(3): e0150223, 2024 Mar 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38315015
2.
Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-32094138
3.
Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A-H clinical isolates and core site-directed mutants in vitro.
J Antimicrob Chemother
; 75(9): 2526-2534, 2020 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32417895
4.
Virology analysis of chronic hepatitis B virus-infected patients treated for 28 days with JNJ-56136379 monotherapy.
J Viral Hepat
; 27(11): 1127-1137, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32579776
5.
Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the Hepatitis B Virus Life Cycle.
Antimicrob Agents Chemother
; 62(10)2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30012770
6.
Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus.
Antimicrob Agents Chemother
; 61(8)2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28584155
7.
Virologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202).
J Hepatol
; 58(3): 445-51, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23142061
8.
Molecular elucidation of drug-induced abnormal assemblies of the hepatitis B virus capsid protein by solid-state NMR.
Nat Commun
; 14(1): 471, 2023 01 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36709212
9.
TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
Antimicrob Agents Chemother
; 56(9): 4676-84, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22710121
10.
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.
Bioorg Med Chem Lett
; 22(13): 4437-43, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22633687
11.
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.
Bioorg Med Chem Lett
; 22(13): 4431-6, 2012 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22542193
12.
Antiviral activity and mode of action of TMC647078, a novel nucleoside inhibitor of the hepatitis C virus NS5B polymerase.
Antimicrob Agents Chemother
; 55(8): 3812-20, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21576430
13.
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex.
Proc Natl Acad Sci U S A
; 105(38): 14545-50, 2008 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-18799730
14.
Development of a cellular high-content, immunofluorescent HBV core assay to identify novel capsid assembly modulators that induce the formation of aberrant HBV core structures.
J Virol Methods
; 293: 114150, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33839187
15.
In vitro resistance profile of the hepatitis C virus NS3/4A protease inhibitor TMC435.
Antimicrob Agents Chemother
; 54(5): 1878-87, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20176898
16.
Correction to: Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects.
Adv Ther
; 37(4): 1703, 2020 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-32133584
17.
Pharmacokinetics, Safety and Tolerability of JNJ-56136379, a Novel Hepatitis B Virus Capsid Assembly Modulator, in Healthy Subjects.
Adv Ther
; 36(9): 2450-2462, 2019 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31267367
18.
Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation.
Front Mol Biosci
; 6: 67, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31440516
19.
Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV).
J Med Chem
; 61(14): 6247-6260, 2018 07 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29906396
20.
Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
Angew Chem Int Ed Engl
; 51(19): 4637-40, 2012 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-22473861